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Drug intelligence / Profile preview
ilorasertib
- Development stage
- Phase 1
- Lead developer
- AbbVie
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Ilorasertib is an orally bioavailable, ATP-mimetic small molecule that acts as a multitargeted kinase inhibitor. It selectively inhibits Aurora kinases (A, B, and C), vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs), and the Src family of tyrosine kinases. By inhibiting these targets, ilorasertib disrupts mitotic checkpoint control and angiogenesis pathways critical for tumor cell proliferation and survival. Developed by AbbVie (originating from Abbott Laboratories) as an antineoplastic agent, it has been investigated primarily in hematologic malignancies such as acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS), as well as in advanced solid tumors. Clinical trials reached up to phase II before development was discontinued for solid tumors[1][2][3][4][5][7].
- Other names
- ilorasertibIlorasertib [USAN]1227939-82-3
02
Targets
AURKA (Aurora kinase A)AURKB (Aurora kinase B)AURKC (Aurora kinase C)CSF1R (Macrophage colony-stimulating factor receptor)FLT3 (Fms related receptor tyrosine kinase 3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDGFRA (Platelet-derived growth factor receptor alpha)PDGFRB (Platelet-derived growth factor receptor beta)RET (Rearranged during transfection receptor tyrosine kinase)SFK (SRC family kinases)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)
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