Drug intelligence / Profile preview

IMD-Omega

Development stage
Unknown
Lead developer
InterMed Discovery
Modality
Small Molecules
Administration
Oral
01

Overview

IMD-Omega is a novel liquid crystalline nanoparticle-based oral formulation of omega-3 acid ethyl esters, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) ethyl esters, developed by IMD Pharm Inc. for the management of hyperlipidemia and hypertriglyceridemia. The formulation is designed to overcome the bioavailability limitations of conventional omega-3 products by spontaneously forming liquid crystalline nanoparticles in the gastrointestinal tract, which significantly enhances the dissolution and permeability of the lipophilic fatty acids. In clinical trials, IMD-Omega demonstrated a 1.7- to 2.3-fold increase in bioavailability compared to the reference product Omacor (Lovaza), allowing for a reduced daily dose (580 mg vs. 1000 mg) and a lower pill burden for patients while maintaining therapeutic efficacy and a favorable safety profile.

Brand names
IMD-Omega
Other names
omega-3 acid ethyl ester 90omega3 acid ethyl ester 90omega 3 acid ethyl ester 90
02

Targets

DGAT1 (Diacylglycerol O-acyltransferase 1)PPARA (Peroxisome proliferator-activated receptor alpha)SREBP-1 / SREBF1 (SREBP-1)

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