Drug intelligence / Profile preview

iMDC-735

Development stage: Preclinical
Lead developer: Cellis
Modality: iPSCs → Pluripotent Stem Cells → Stem Cell Therapies → Cell Therapies

Overview

iMDC-735 is an induced pluripotent stem cell (iPSC)-derived macrophage-drug conjugate (MDC) currently in preclinical development by Cellis for the treatment of glioblastoma. As the iPSC-derived counterpart to the company's lead candidate MDC-735, iMDC-735 leverages the innate ability of macrophages to cross the blood-brain barrier and infiltrate the immunosuppressive tumor microenvironment of glioblastoma. By using an iPSC-based manufacturing platform, Cellis aims to produce a standardized, off-the-shelf cell therapy that delivers a cytotoxic payload directly to tumor cells, potentially overcoming the limitations of primary cell-derived therapies. The program is currently undergoing preclinical evaluation with plans to advance into Phase I/II clinical trials.

Other names: iPSC-derived MDC-735iPSC-derived Macrophage-Drug Conjugate 735

Targets

TUBB (Tubulin (alpha and beta subunits))

Beyond the preview

Go deeper on iMDC-735.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on iMDC-735.

Explore the full profile