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IMDQ-PC
- Development stage
- Preclinical
- Lead developer
- Ghent University
- Modality
- Small Molecules
- Administration
- Intramuscular
01
Overview
IMDQ-PC (imidazoquinoline-poly(ethylene glycol)-cholesterol conjugate) is an experimental lipid amphiphile imidazoquinoline conjugate that acts as a Toll-like receptor 7/8 (TLR7/8) agonist. Developed by Ghent University and the Icahn School of Medicine at Mount Sinai, it is designed as a lymph node-draining vaccine adjuvant to enhance immune responses, particularly Th1-biased humoral and cellular immunity. It has been evaluated in preclinical models as an adjuvant for various vaccines, including inactivated influenza vaccines, SARS-CoV-2 spike protein vaccines, HIV V1V2-scaffold vaccines, and severe fever with thrombocytopenia syndrome virus (SFTSV) vaccines.
- Other names
- imidazoquinoline-PEG-ChoIimidazoquinoline-PEG-Cholimidazoquinoline-PEG-cholesterolimidazoquinoline-PEG-cholesterol conjugateimidazoquinoline-poly(ethylene glycol)-cholesterol conjugate
02
Targets
TLR7 (Toll-like receptor 7)TLR8 (Toll-like receptor 8)
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