imidacloprid + moxidectin

Imidacloprid + moxidectin is a topical combination drug approved for veterinary use in dogs and cats to prevent and treat infestations by a broad spectrum of internal and external parasites. **Imidacloprid** is a neonicotinoid insecticide that targets the nicotinic acetylcholine receptors of insects, leading to nervous system impairment and rapid death of fleas. **Moxidectin** is a macrocyclic lactone (avermectin) that binds to glutamate-gated chloride channels in invertebrate nerve and muscle cells, causing paralysis and death of nematodes and other parasites. This combination provides monthly protection against fleas, heartworm disease (Dirofilaria immitis), and various gastrointestinal nematodes (roundworms, hookworms, whipworms), and ear mites in cats. It is supplied as a **topical solution** for application on the skin and is not absorbed systemically. The combination does not interfere with the independent activity of either ingredient and is regarded as safe for the indicated species when used according to labeling. It is not approved for human use.

Brand names

Imoxi

Other names

imidacloprid/moxidectinAdvantage Multi for DogsAdvantage Multi for CatsImoxi Topical Solution for Cats