Immucillin-G

Immucillin-G is a chemically stable small molecule analog that mimics the transition state of N-ribosyltransferase enzymes. It acts as a potent inhibitor of purine nucleoside phosphorylase (PNP), an enzyme critical for the purine salvage pathway. By inhibiting PNP, Immucillin-G blocks the recycling of purines necessary for DNA and RNA synthesis in certain pathogens and host cells. This leads to apurinic starvation and cell death in organisms dependent on this pathway, such as Plasmodium falciparum (the malaria parasite). Immucillin-G has shown clinical potential primarily as an antimalarial agent but may also have applications in other infectious diseases where ribosyltransferase chemistry is essential[1][2][3][5].

Other names

(1S)-1,4-dideoxy-1,4-imino-1-(9-deazaguanin-9-yl)-D-ribitol