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immune globulin + ganciclovir
- Development stage
- Unknown
- Lead developer
- Roche
- Modality
- Small Molecules, Antibody-Based Therapeutics
01
Overview
Immune globulin + ganciclovir is a combination therapy investigated for the treatment of sight-threatening cytomegalovirus (CMV) retinitis, particularly in patients with AIDS. The combination utilizes ganciclovir, a synthetic nucleoside analogue of 2'-deoxyguanosine that inhibits CMV replication by acting as a competitive inhibitor of dGTP incorporation into viral DNA via CMV DNA polymerase. The addition of immune globulin (IVIG) provides passive immunization through a pool of polyvalent IgG antibodies, which can neutralize CMV virions and provide immunomodulatory effects. This specific combination was studied by the American National Red Cross in a pilot trial to determine if it could provide a faster initial response and longer duration of remission compared to ganciclovir monotherapy in immunocompromised individuals.
- Other names
- immune globulin and ganciclovirIVIG + ganciclovirimmune globulin and ganciclovir combination
02
Targets
CMV DNA polymerase (Human cytomegalovirus DNA polymerase)HCMV surface antigens (Human cytomegalovirus surface antigens)
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