immune globulin 10%

Immune globulin 10% (human) is a sterile, liquid formulation of highly purified immunoglobulin G (IgG) antibodies derived from large pools of human plasma. This 10% concentration is a standard strength for several intravenous and subcutaneous immunoglobulin therapies, providing a broad spectrum of opsonizing and neutralizing IgG antibodies against bacterial, viral, and other pathogens, as well as immunomodulatory effects. In the context of Takeda Pharmaceutical Company's portfolio, this formulation (marketed as Gammagard Liquid or Kiovig) serves as the primary therapeutic component in HYQVIA (TAK-771), a facilitated subcutaneous immunoglobulin (fSCIG) system. In HYQVIA, the 10% immune globulin is co-administered with recombinant human hyaluronidase, which temporarily increases subcutaneous tissue permeability to allow for the infusion of large volumes of IgG. It is indicated for the treatment of primary immunodeficiency (PID) and autoimmune neuromuscular disorders, including chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and multifocal motor neuropathy (MMN).

Brand names

Gammagard LiquidKiovigPanzygaPrivigenOctagam 10%

Other names

immune globulin infusion 10% (human)human normal immunoglobulin 10%IVIG 10%IG 10%fSCIG 10% component