immune serum globulin

Immune serum globulin is a **sterile solution of immunoglobulin G (IgG) purified from pooled human plasma**, used primarily for passive immunization against infections such as hepatitis A, measles, varicella (chickenpox), and rubella, and as immunoglobulin replacement in individuals with antibody deficiencies. The product works by providing exogenous IgG antibodies, which confer **immediate, short-term protection** by neutralizing pathogens or their toxins, modulating immune responses, and supporting immune-deficient individuals. It is used both at replacement dosing (antibody deficiency) and higher immunomodulatory doses for various autoimmune, neurologic, hematologic, and dermatologic conditions. The mechanism involves **neutralization of viruses and toxins, modulation of Fc receptor function, inhibition of pathogenic autoantibodies, and anti-inflammatory immunomodulation**[1][2][3][7][9][10].

Brand names

HizentraPrivigenGammagard LiquidFlebogammaCutaquigXembifyCuvitruXepolGamunex-CGammakedOctagamPanzyga

Other names

immune globulin humanimmune globulingamma globulinimmunoglobulinISGimmune serum globulin humanimmune serumimmunoglobulin G