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Imprimis Less Drops
- Development stage
- Unknown
- Lead developer
- Harrow
- Modality
- Small Molecules
- Administration
- Ophthalmic
01
Overview
Imprimis Less Drops is a compounded topical ophthalmic regimen developed by Imprimis Pharmaceuticals for the management of postoperative inflammation and the prevention of infection following cataract surgery. The regimen typically consists of two distinct compounded formulations: Pred-Moxi (a combination of the corticosteroid prednisolone and the fluoroquinolone antibiotic moxifloxacin) and Pred-Ketorolac (a combination of prednisolone and the non-steroidal anti-inflammatory drug ketorolac). This "Less Drops" approach aims to simplify the postoperative medication schedule for patients compared to traditional multi-bottle regimens. It has been evaluated in Phase 4 clinical trials as a comparator to intravitreal "Dropless" injections.
- Brand names
- LessDropsLess Drops
- Other names
- Pred-Moxi + Pred-Ketorolac regimen
02
Targets
Topo IV (Bacterial Topoisomerase IV)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)GR (Glucocorticoid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)DNA gyrase
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