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IMT-009 + fruquintinib
- Development stage
- Phase 2
- Lead developer
- Immunitas Therapeutics
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
IMT-009 + fruquintinib is an investigational combination therapy consisting of IMT-009, a monoclonal antibody targeting CD161, and fruquintinib, an oral small molecule inhibitor that blocks vascular endothelial growth factor receptors (VEGFR). IMT-009 is designed to modulate immune responses by binding to CD161, which is expressed on certain immune cells, potentially enhancing anti-tumor immunity. Fruquintinib acts as an anti-angiogenic agent by inhibiting VEGFRs, thereby blocking the blood supply to tumors. This combination is currently being evaluated for safety, tolerability, and preliminary efficacy in patients with relapsed or refractory Hodgkin lymphoma and T-cell lymphoma in phase 1 and phase 2 clinical trials. IMT-009 is developed by Immunitas Therapeutics, while fruquintinib is developed by HUTCHMED and marketed as Fruzaqla by Takeda in the United States for metastatic colorectal cancer[1][2][3][4].
- Other names
- IMT-009 and fruquintinib combinationIMT009 and fruquintinib combinationIMT 009 and fruquintinib combination
02
Targets
KLRB1 (C-type lectin-like receptor CD161)FGFR1 (Fibroblast growth factor receptor 1)RET (Rearranged during transfection receptor tyrosine kinase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)KIT (c-KIT proto-oncogene receptor tyrosine kinase)
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