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**IMU-366** is an orally available small molecule inverse agonist of RORγt (RORgT), a nuclear receptor that regulates the differentiation of Th17 T cells and the production of pro-inflammatory cytokines involved in autoimmune diseases. Developed by Immunic Therapeutics following acquisition from 4SC, it demonstrated efficacy in preclinical models of immune and autoimmune conditions. Primarily targeted for autoimmune diseases such as psoriasis, it offers potential for broader applications in Th17-mediated disorders due to its selective modulation of cytokine expression without broad immunosuppression.[1][2][5][8]
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