Drug intelligence / Profile preview

IN-C009

Development stage
Phase 1
Lead developer
HK inno.N Corporation
Modality
Small Molecules
Administration
Oral
01

Overview

IN-C009 is an oral fixed-dose combination tablet containing **dapagliflozin 10 mg** and **linagliptin 5 mg**, developed by HK inno.N for type 2 diabetes mellitus. Dapagliflozin selectively inhibits sodium-glucose cotransporter 2 in the kidney, increasing urinary glucose excretion, while linagliptin reversibly inhibits dipeptidyl peptidase 4, prolonging endogenous incretin activity and enhancing glucose-dependent insulin secretion. A randomized crossover pharmacokinetic study in healthy adults found that the fixed-dose product had pharmacokinetic exposure comparable to co-administered individual dapagliflozin and linagliptin tablets and was safe and tolerable. ([mdpi.com](https://www.mdpi.com/1999-4923/14/3/591))

Other names
dapagliflozin + linagliptindapagliflozin/linagliptin
02

Targets

SGLT2 (Sodium-glucose cotransporter protein subunit 2)

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