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IN01
- Development stage
- Phase 1
- Lead developer
- Instituto Oncológico Dr Rosell
- Modality
- Vaccines & Immunotherapeutics, Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes
- Administration
- Oral
01
Overview
**IN01** is an investigational therapeutic anti-epidermal growth factor vaccine developed by IN3BIO. It is a recombinant biologic fusion-protein vaccine incorporating a synthetic epidermal growth factor variant; vaccination induces polyclonal neutralizing anti-EGF antibodies that sequester EGF and prevent activation of the epidermal growth factor receptor signaling axis. IN01 has been investigated for KRAS-, NRAS-, or BRAF-mutated colorectal cancer, including in combination with targeted small-molecule inhibitors, and in a Phase Ib study for post-COVID-19 fibrosing interstitial lung disease. It is mixed with Montanide ISA 51 VG ST adjuvant before administration as a water-in-oil emulsion. ([prnewswire.com](https://www.prnewswire.com/news-releases/in3bio-gains-approval-for-phase-iii-clinical-trial-301319282.html))
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