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IN10018 + RNK08954
- Development stage
- Unknown
- Lead developer
- InxMed (Shanghai) Co., Ltd.
- Modality
- PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
IN10018 + RNK08954 is a combination therapy being developed by InxMed (Shanghai) Co., Ltd. for the treatment of KRASG12D mutation-positive advanced solid tumors. IN10018 (ifebemtinib) is a potent and selective oral small molecule inhibitor of focal adhesion kinase (FAK), which plays a critical role in modulating the tumor microenvironment and overcoming resistance to various targeted therapies. RNK08954 is a targeted protein degrader specifically designed to target and degrade the KRASG12D mutant protein. This combination aims to synergistically inhibit oncogenic signaling and improve clinical outcomes in patients with pancreatic ductal adenocarcinoma, non-small cell lung cancer, and colorectal cancer harboring the KRASG12D mutation.
- Other names
- ifebemtinib + RNK08954
02
Targets
FAK (Focal adhesion kinase)KRASG12D (Kirsten rat sarcoma viral oncogene homolog (KRAS) G12D mutant)
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