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inactivated Akkermansia muciniphila
- Development stage
- Phase 4
- Lead developer
- Shanghai East Hospital
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Inactivated Akkermansia muciniphila (specifically strain Akk11 in the context of Shanghai East Hospital) is a microbial therapy consisting of pasteurized or heat-killed bacteria. Unlike live biotherapeutics, the inactivated form of this gut commensal has been shown to retain or even enhance its metabolic benefits, particularly in improving intestinal barrier function and insulin sensitivity. The primary mechanism involves the interaction of the outer membrane protein Amuc_1100 with Toll-like receptor 2 (TLR2) on the intestinal epithelium. This interaction triggers signaling pathways that strengthen tight junctions and reduce metabolic endotoxemia. It is currently being investigated in Phase 4 clinical trials for the treatment of polycystic ovary syndrome (PCOS) and obesity, often as an adjunct to metformin therapy.
- Other names
- pasteurized Akkermansia muciniphilaheat-killed Akkermansia muciniphilaAkkermansia muciniphila (inactivated)
02
Targets
FFAR2FFAR3 (Free fatty acid receptor 3)TLR2 (Toll-like Receptor 2)TLR1TLR4 (Toll-like receptor 4)
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