Inactivated influenza vaccine (University of Bergen)

The inactivated influenza vaccine (University of Bergen) refers to the vaccine intervention utilized in the **FluEffect** trial (NCT04118426), a Phase IV cluster-randomized effectiveness study conducted in rural Bangladesh. Led by the University of Bergen, the trial evaluates the impact of maternal and pediatric influenza vaccination on reducing influenza-related illness and mortality in a low-income setting. The vaccine works by presenting inactivated (killed) influenza virus particles to the immune system, stimulating the production of neutralizing antibodies against the viral hemagglutinin protein. This study specifically targets pregnant women and children aged 6-59 months to assess both direct clinical protection and indirect community-level effects (herd immunity) in a region where influenza is a major contributor to childhood pneumonia and maternal morbidity.

Other names

IIVInactivated influenza vaccine