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inactivated Lactobacillus reuteri
- Development stage
- Unknown
- Lead developer
- Shenzhen People's Hospital
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Inactivated Lactobacillus reuteri is a heat-killed microbial preparation, often referred to as a postbiotic, being studied by Shenzhen People's Hospital for its therapeutic potential in treating skin barrier impairment. In the context of clinical research, it is administered orally (1×10^11 CFU) to individuals with obesity-induced skin barrier damage. The preparation is hypothesized to influence the gut-skin axis, potentially modulating systemic inflammation and the gut microbiome to improve skin integrity and reduce transepidermal water loss (TEWL). While often used as a placebo control in probiotic trials, inactivated strains are increasingly investigated for their own distinct biological activities and safety profiles in metabolic and dermatological health.
- Other names
- heat-killed Lactobacillus reuteriinactive Lactobacillus reuteri
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