inactivated pepsin fraction

Inactivated pepsin fraction is an experimental **biologic peptide/protein therapeutic** derived from pepsin and developed by Viral Genetics. It has been described as a modified pepsin-derived fraction with an apparent molecular weight of about 45 kDa, produced by isolating active pepsin and then inactivating and purifying it through pH manipulation, precipitation, and reverse-phase high-pressure liquid chromatography. The proposed mechanism is atypical and incompletely validated, but reported work attributes activity to binding interactions with HIV-1 envelope components including gp120 and gp41, interactions involving CD4-positive cells, and modulation of the heat shock protein gp96, with downstream immunomodulatory and potential antiviral effects. The agent was primarily investigated for HIV/AIDS, with additional exploratory claims in hepatitis, multiple sclerosis, lupus, herpes simplex infection, and cancer-related immune modulation, but no approved product or well-established late-stage development program is evident from the provided context.

Other names

inactivated pepsin fractionIPF