inactivated poliovirus vaccine (fractional dose) + bivalent oral polio vaccine

This is a combination immunization regimen using two types of poliovirus vaccines: - **Fractional Inactivated Poliovirus Vaccine (fIPV):** A reduced-dose (1/5th of the full dose) inactivated poliovirus vaccine administered intradermally. It induces immunity against all three types of polioviruses and is used to optimize limited IPV supply while maintaining high immunogenicity[8][7][1]. - **Bivalent Oral Polio Vaccine (bOPV):** An oral live attenuated vaccine that protects against poliovirus types 1 and 3 but not type 2[3][2]. The sequential schedule typically involves two doses of fIPV followed by two or three doses of bOPV during infancy. This approach provides robust protection against all wild-type polioviruses and supports global eradication efforts by maximizing immune response while conserving IPV supplies[1][3]. The mechanism of action for both components is induction of protective immunity via stimulation of humoral and mucosal immune responses.

Other names

fractional IPV + bOPVf-IPV + bOPVfractional-dose inactivated polio vaccine + bivalent oral polio vaccine