inactivated whole virion pandemic influenza vaccine

The inactivated whole virion pandemic influenza vaccine is a biologic agent developed for the prevention of influenza caused by pandemic strains, such as H5N1. Unlike split-virion or subunit vaccines, this formulation contains the entire inactivated virus particle, which preserves the structural integrity of viral proteins and provides natural toll-like receptor (TLR) ligands that act as endogenous adjuvants. This specific vaccine program, associated with Stichting Leveronderzoek and Nobilon, utilized a cell-culture-based production platform to generate monovalent H5N1 (A/Vietnam/1194/2004) antigens. Clinical evaluation in Phase 1 trials focused on assessing safety and the ability to induce robust hemagglutination inhibition (HI) titers in healthy adults, comparing its performance to seasonal whole virion and commercial subunit vaccines.

Other names

whole virion influenza vaccineWVV pandemic influenza vaccineinactivated whole virion H5N1 vaccine