inactivated whole-virus influenza vaccine

The inactivated whole-virus influenza vaccine developed by Changchun Changsheng Biological Life Science Institute Co., Ltd. is a prophylactic vaccine designed to prevent seasonal influenza infection. Unlike split-virion or subunit vaccines, this whole-virion formulation contains the entire inactivated influenza virus particle. This approach typically results in higher immunogenicity due to the presence of all viral proteins and endogenous viral RNA, which can act as a natural adjuvant by stimulating Toll-like receptors. However, whole-virion vaccines are also associated with a higher incidence of febrile reactions compared to more processed vaccine types. The development of this specific vaccine candidate was terminated following a major regulatory scandal in 2018 involving the fabrication of production records at Changsheng Bio, which led to the revocation of the company's pharmaceutical licenses and its subsequent bankruptcy.

Other names

Whole Virion Inactivated Influenza VaccineChangsheng Influenza Vaccine