indapamide

Indapamide is a thiazide-like diuretic (water pill) used primarily to treat high blood pressure (hypertension) and edema associated with congestive heart failure. It works by inhibiting sodium and chloride reabsorption in the distal convoluted tubule of the kidney, leading to increased excretion of water and salts, which reduces fluid retention and lowers blood pressure. Indapamide also exhibits direct vasodilatory effects on vascular smooth muscle, likely through reduction of calcium influx, contributing further to its antihypertensive action. It is available as an oral tablet and is typically prescribed once daily[1][3][5][6][8].

Brand names

Lozol

Other names

(S)-IndapamideIndapamidaIndapamidumflupamidindamide4-chloro-N-(2-methyl-2,3-dihydroindol-1-yl)-3-sulfamoylbenzamide4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamideBenzamide, 3-(aminosulfonyl)-4-chloro-N-(2,3-dihydro-2-methyl-1H-indol-1-yl)-