Drug intelligence / Profile preview

indatraline

Development stage
Preclinical
Lead developer
Lundbeck
Modality
Small Molecules
Administration
Oral (experimental)
01

Overview

Indatraline is a non-selective monoamine reuptake inhibitor that blocks the reuptake of dopamine, norepinephrine (noradrenaline), and serotonin with similar efficacy to cocaine. It acts as an antidepressive agent and has been studied for its potential use in treating cocaine addiction due to its slower onset and longer duration of action compared to cocaine. Indatraline produces behavioral effects suggestive of enhanced dopaminergic, noradrenergic, and serotonergic activity in animal models. It has also been shown to block the action of methamphetamine and MDMA in laboratory experiments[1][2][3][4]. The compound is typically used experimentally rather than clinically.

Other names
indatraline hydrochloride(+/-)-trans-3-(3,4-dichlorophenyl)-N-methyl-1-indanamineIndatralinum
02

Targets

SERT (Sodium-dependent serotonin transporter)NET (Norepinephrine Transporter)DAT (Dopamine plasma membrane transport protein)

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