indirubin-5-sulphonate

Indirubin-5-sulphonate is a synthetic small molecule derivative of indirubin, belonging to the class of indoline compounds. It acts as a potent and selective inhibitor of cyclin-dependent kinases (CDKs), including CDK1/cyclin B, CDK2/cyclin A/E, CDK4/cyclin D1, and CDK5/p35. Additionally, it inhibits glycogen synthase kinase 3 beta (GSK‑3β). These kinases are key regulators of cell cycle progression and neuronal signaling pathways. Indirubin derivatives have been studied for their anti-tumor properties and potential roles in modulating abnormal tau phosphorylation relevant to neurodegenerative diseases such as Alzheimer's disease[1][2][10]. Indirubin itself is an active constituent in traditional Chinese medicine for leukemia; however, indirubin‑5‑sulphonate is primarily used experimentally in research settings.

Other names

Indirubin-5-sulfonic acidIndirubin5-sulfonic acidIndirubin 5-sulfonic acidIndirubin 5-SulfonateIndirubin5-SulfonateIndirubin-5-Sulfonate(Z)-2',3-dioxo-1',2'-dihydro-1H,3H-(2,3'-biindolylidene)-5'-sulfonic acid(Z)-2',3-dioxo-1',2'-dihydro-1H,3H-[2,3'-biindolylidene]-5'-sulfonic acid