indium-111 anti-CD8 antibody

Indium-111 anti-CD8 antibody is a radiolabeled monoclonal antibody or antibody fragment designed for non-invasive imaging of CD8+ T-cell infiltration using single-photon emission computed tomography (SPECT) or SPECT/CT. The imaging agent consists of an anti-CD8 targeting moiety (such as a monoclonal antibody or a one-armed antibody fragment) conjugated to a chelator (such as DOTA or DTPA) and radiolabeled with the gamma-emitting isotope indium-111. By binding specifically to the CD8 glycoprotein expressed on cytotoxic T lymphocytes, this radiopharmaceutical allows for the visualization and quantification of CD8+ T-cell distribution in vivo. It is being investigated in preclinical models for monitoring immune cell infiltration in autoimmune diseases like type 1 diabetes (T1D) and tracking tumor-infiltrating lymphocytes in cancer immunotherapy.

Other names

[111In]In-anti-CD8111In-anti-CD8111In-labeled anti-CD8111In-labeled anti-CD8 antibodyindium-111-labeled anti-CD8 antibodyindium111-labeled anti-CD8 antibodyindium 111-labeled anti-CD8 antibody