Drug intelligence / Profile preview

indium-111 chloride

Development stage
Unknown
Lead developer
Mallinckrodt
Modality
Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration
Intravenous (for End Radiolabeled Product)
01

Overview

**Indium-111 chloride** is a radiopharmaceutical precursor used in nuclear medicine for *radiolabeling* monoclonal antibodies, peptides, and other proteins for in vivo diagnostic imaging and investigational procedures[1][3][4][5][7]. The compound consists of the radioactive isotope indium-111, which emits gamma radiation with a half-life of about 2.8 days, suitable for medical imaging via gamma cameras[1][5][7].\nIts primary function is as a radioactive tracer: it is used to radiolabel agents (such as monoclonal antibodies for tumor targeting, or leukocytes for infection site localization) which are subsequently injected into a patient for detection and characterization of diseases including cancer, infections, inflammation, bone marrow disorders, gastrointestinal bleeding, and various lymphatic abnormalities[1][7].\nThe mechanism of action of indium-111 chloride alone relates solely to its use as a radiolabeling agent; the biological activity and targeting is conferred by the labeled molecule (e.g., antibody, peptide, blood cells)[7].

Brand names
IndiclorOctreoscan
Other names
Indium (111In) chlorideIndium In 111 chlorideIndium In-111 chlorideIndium-111 chlorideIndium111 chlorideIndium 111 chloride

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