indocyanine green + core-shell porous silica nanoparticles + polyethylene glycol

ICG-CPSNP is a theranostic nanoparticle platform composed of the near-infrared (NIR) fluorophore indocyanine green (ICG) encapsulated within a calcium phosphosilicate (CPSN) matrix, typically surface-functionalized with polyethylene glycol (PEG). Developed by Keystone Nano in collaboration with researchers at Penn State University and the University of Virginia, the platform is utilized in a therapeutic modality termed PhotoImmunoNanoTherapy (PINT). Upon NIR irradiation, the encapsulated ICG acts as a photosensitizer, generating reactive oxygen species (ROS) that induce direct tumor cell death and modulate the tumor microenvironment. Mechanistically, PINT has been shown to decrease tumor-associated inflammation and systemic immunosuppression by reducing the expansion of immature myeloid cells (MDSCs) in a sphingosine kinase 2 (SphK2)-dependent manner. This process involves the induction of bioactive sphingolipids, such as dihydrosphingosine-1-phosphate (dhS1P), which selectively abrogate myeloid lineage cells while allowing for the expansion of antitumor lymphocytes. The platform is also utilized for deep-tissue imaging and sentinel lymph node mapping.

Other names

PhotoImmunoNanoTherapyPINTICG-PEG-CPSNPindocyanine green-loaded calcium phosphosilicate nanoparticlesICG-loaded calcium phosphosilicate nanoparticles