Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
indocyanine green-loaded polymeric nanoparticles
- Development stage
- Unknown
- Lead developer
- Nada Mahmoud Soliman
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Topical
01
Overview
Indocyanine green-loaded polymeric nanoparticles are an experimental drug delivery system designed for antimicrobial photodynamic therapy (aPDT) in the treatment of periodontitis. This formulation, investigated by Nada Mahmoud Soliman, utilizes biodegradable polymeric nanoparticles to encapsulate indocyanine green (ICG), a tricarbocyanine dye that acts as a photosensitizer. When applied to periodontal pockets and irradiated with a diode laser (typically 810 nm), the ICG molecules transition to an excited state and transfer energy to molecular oxygen, generating reactive oxygen species (ROS) such as singlet oxygen. These ROS cause oxidative damage to the cell membranes and DNA of periodontal pathogens, leading to bacterial cell death. The nanoparticle carrier is intended to improve the stability of ICG and enhance its penetration and retention within the subgingival environment compared to free ICG solutions.
- Other names
- ICG-loaded nanoparticlesICG-NP
02
Targets
LPS (Lipopolysaccharide)
Beyond the preview
Go deeper on indocyanine green-loaded polymeric nanoparticles.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on indocyanine green-loaded polymeric nanoparticles.