indoleamine 2,3-dioxygenase 1 PROTAC

Indoleamine 2,3-dioxygenase 1 (IDO1) PROTACs are a class of proteolysis targeting chimera (PROTAC) small molecules designed to degrade the IDO1 protein via the ubiquitin-proteasome system. IDO1 is an immunosuppressive enzyme that facilitates tumor immune evasion by depleting tryptophan and producing kynurenine, as well as through non-enzymatic signaling. Unlike traditional IDO1 inhibitors that only block enzymatic activity, PROTACs eliminate the protein entirely, potentially overcoming resistance mechanisms and addressing non-catalytic functions of IDO1. Research compounds like NU227326 and NU223612 have shown potent degradation (DC50 in the nanomolar range) and efficacy in preclinical models of glioblastoma (GBM) by improving survival and reducing intratumoral IDO1 levels.

Other names

IDO1 PROTACIDO-1 PROTACIDO 1 PROTACIDO1 protein degraderIDO-1 protein degraderIDO 1 protein degrader