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infection and transmission blocking malaria bispecific vaccine
- Development stage
- Preclinical
- Lead developer
- Versatope Therapeutics
- Modality
- Nanoparticles → Drug Delivery Systems, Vaccines & Immunotherapeutics
01
Overview
Versatope Therapeutics is developing a bi-specific malaria vaccine designed to block both the initial infection and the transmission of the parasite. The vaccine utilizes Versatope's proprietary Recombinant Extracellular Transport Vesicle (RET-V) platform, which is based on recombinant outer membrane vesicles (rOMVs) derived from genetically engineered bacteria. This approach aims to provide dual protection by targeting the pre-erythrocytic stage (to prevent infection) and the sexual stages (to prevent transmission to mosquitoes). The project is supported by a $3 million grant from the National Institute of Allergy and Infectious Diseases (NIAID).
- Other names
- bi-specific malaria vaccinemalaria bispecific vaccine
02
Targets
CSP (Circumsporozoite protein)
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