inflachromene

Inflachromene is a small molecule chromene derivative that acts as a potent inhibitor of High Mobility Group Box proteins, specifically HMGB1 and HMGB2. Originally identified for its anti-inflammatory properties, inflachromene works by binding to HMGB proteins and sequestering them, thereby preventing their pro-inflammatory signaling and nucleocytoplasmic translocation. In oncology research, particularly in glioblastoma (GBM), inflachromene has been identified as a potential radiosensitizer. It targets glioblastoma stem cells (GSCs) to overcome radioresistance, a major hurdle in GBM treatment. By inhibiting HMGB2, inflachromene reduces the self-renewal capacity and neurosphere formation of GSCs, enhancing the efficacy of radiotherapy. Research suggests that the molecule interferes with the chromatin-binding functions of HMGB2, which are critical for the survival of resistant tumor cell populations.

Other names

2-(4-chlorophenyl)-4-(3,4-dimethoxyphenyl)-7-methoxy-4H-chromene