Drug intelligence / Profile preview

Influenza A (H5N1) vaccine

Development stage
Phase 3
Lead developer
CSL Seqirus
Modality
Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Whole Inactivated Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration
Intramuscular
01

Overview

The influenza A (H5N1) vaccine is an inactivated or split-virion monovalent vaccine designed to provide immunization against the H5N1 subtype of the influenza A virus. It works by inducing the body to produce antibodies targeting the hemagglutinin protein of H5N1, thereby neutralizing viral infectivity and preventing disease. The vaccines may be adjuvanted (e.g., with AS03) to enhance immune response and are administered intramuscularly. They are primarily indicated for individuals at increased risk of exposure to H5N1 avian influenza and can be updated as new strains emerge. Several formulations have been developed for both human and veterinary use; some are stockpiled for pandemic preparedness[3][4][5][6].

Brand names
AudenzAflunovArepanrixCelldemic
Other names
influenza a virus vaccine h5n1 adjuvantedavian influenza (h5n1) vaccineh5n1 pandemic vaccineh-5n1 pandemic vaccineh 5n1 pandemic vaccine
02

Targets

HA (Hemagglutinin)

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