influenza A (H5N1) whole-virus vaccine

Influenza A (H5N1) whole-virus vaccine is a **pandemic influenza vaccine approach** consisting of chemically inactivated, non-replicating whole influenza A H5N1 virions formulated for prophylactic immunization against avian-origin H5N1 influenza. As a whole-virus vaccine, it presents the immune system with the intact virion and therefore exposes multiple viral antigens, principally hemagglutinin and neuraminidase, to induce neutralizing and other functional antibody responses and cellular immunity that can help prevent H5N1 influenza infection or severe disease. The term most commonly refers to investigational or stockpiled prepandemic H5N1 vaccines, including Vero cell-derived and other inactivated whole-virion products studied in adults and risk groups, rather than a single uniquely branded product; development has involved multiple groups including Baxter and Japanese manufacturers for prepandemic use.

Other names

influenza A (H5N1) whole-virus vaccineH5N1 influenza vaccine whole virionH-5N1 influenza vaccine whole virionH 5N1 influenza vaccine whole virionwhole virion, vero cell-derived, inactivated influenza vaccine, non-adjuvantedinactivated whole-virion H5N1 vaccineinactivated H5N1 whole-particle influenza vaccine