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**Influenza vaccine inactivated split trivalent nonadjuvanted** is a **split virion, inactivated seasonal vaccine** formulated to protect against three influenza virus strains: one influenza A(H1N1), one influenza A(H3N2), and one influenza B (Victoria lineage). It is produced by inactivating and splitting the virus, resulting in a vaccine containing surface antigens (primarily hemagglutinin and neuraminidase) that induce an immune response without risk of causing influenza infection. The vaccine works by stimulating the production of virus-neutralizing antibodies against the included strains, offering protection from future infection. The trivalent, split, nonadjuvanted vaccines do not contain added adjuvants and are generally administered intramuscularly. As of the 2025-2026 season, all U.S. influenza vaccines are trivalent, reflecting the absence of circulating influenza B/Yamagata lineage viruses[1][2][3][4][7].
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