Drug intelligence / Profile preview

INFLUSOME-VAC

Development stage
Unknown
Lead developer
Hadassah Medical Organization
Modality
Nanoparticles → Drug Delivery Systems, Vaccines & Immunotherapeutics
Administration
Intranasal
01

Overview

**INFLUSOME-VAC** is an investigational liposomal influenza subunit vaccine developed at the Hebrew University-Hadassah Medical School and clinically evaluated by Hadassah Medical Organization. The formulation incorporates influenza-virus surface antigens, hemagglutinin and neuraminidase, in liposomes with cytokine adjuvant activity reported for interleukin-2 or granulocyte-macrophage colony-stimulating factor. It was designed to enhance and prolong systemic and mucosal anti-influenza immune responses, including anti-neuraminidase antibodies, particularly in older or otherwise high-risk populations. A Hadassah-sponsored clinical study evaluated an intranasal formulation against a commercial intramuscular influenza vaccine. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/11672916/))

Other names
Influsome VacINFLUSOME-VACliposomal intranasal influenza vaccine
02

Targets

CSF2R (Granulocyte-macrophage colony-stimulating factor receptor)HA (Hemagglutinin)IL-2R (Interleukin-2/interleukin-15 receptor complex)Neuraminidase

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