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Infradure
- Development stage
- Phase 2
- Lead developer
- Avalo Therapeutics
- Modality
- Gene Addition/Replacement → Gene Therapies, Gene Editing → Gene Therapies, Gene Silencing → Gene Therapies
- Administration
- Subcutaneous
01
Overview
**Infradure** is a gene therapy based on Medgenics' proprietary Biopump™ platform, utilizing a subcutaneous autologous skin tissue implant derived from the patient's own biopsy to enable sustained production and delivery of **interferon alpha-2b** (IFNα-2b). It targets the **interferon alpha/beta receptor (IFNAR)** to provide continuous therapeutic levels of IFNα for chronic hepatitis treatment, avoiding frequent injections associated with standard IFNα therapies. Developed primarily by **Medgenics** (later associated with **Aevi Genomic Medicine**), it received **FDA orphan drug designation** for **hepatitis D** and was planned for Phase I/II trials in **hepatitis C** in Israel around 2012.[1][3][4][5][7][9]
- Brand names
- InfradureInfradure Biopump
- Other names
- Interferon alpha-2b gene therapy
02
Targets
IFNAR (Immune system modulation via type I interferon receptor)
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