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iniparib + pegylated liposomal doxorubicin + carboplatin
- Development stage
- Phase 3
- Lead developer
- Sanofi
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
This is a **three-drug combination regimen** consisting of **iniparib** (formerly thought to be a PARP inhibitor, now recognized to have cytotoxic effects via an undefined mechanism), **pegylated liposomal doxorubicin** (a liposome-encapsulated formulation of the anthracycline doxorubicin, which intercalates DNA and inhibits topoisomerase II), and **carboplatin** (a platinum-based DNA-damaging chemotherapeutic agent). This combination was evaluated in clinical trials for the treatment of ovarian cancer, in particular for platinum-resistant or recurrent settings. While iniparib was originally believed to act as a PARP inhibitor, subsequent evidence indicates its mechanism is distinct and not canonical PARP inhibition. **Pegylated liposomal doxorubicin** is designed for improved pharmacokinetics and reduced cardiotoxicity compared to conventional doxorubicin. **Carboplatin** induces DNA cross-links, leading to apoptosis.
- Brand names
- None known for this specific combination
- Other names
- None known for this specific combination
02
Targets
DNAPARP1 (Poly (adp-ribose) polymerase 1)TOP2A (DNA topoisomerase II)
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