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Inje cocktail

Development stage: Unknown
Lead developer: Inje University College of Medicine
Modality: Small Molecules
Administration: Oral

Overview

The Inje cocktail is a validated combination of five probe drugs designed for high-throughput in vivo phenotyping of major human cytochrome P450 (CYP) enzyme activities. It is used primarily in clinical pharmacology research to simultaneously assess the metabolic activity of CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A enzymes. The five components are caffeine (CYP1A2), losartan (CYP2C9), omeprazole (CYP2C19), dextromethorphan (CYP2D6), and midazolam (CYP3A). Each drug serves as a specific substrate for its respective enzyme isoform. The mechanism involves administering all five drugs together and measuring their plasma or urine metabolite ratios to determine individual enzyme activity[1][3][8]. This approach enables efficient evaluation of potential drug-drug interactions or genetic differences in metabolism.

Brand names: Inje cocktail
Other names: Inje cocktailfive-drug CYP probe cocktail

Targets

CYP2C19 (Cytochrome P450 2C19)CYP1A2 (Cytochrome P450 1A2)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)CYP3A7 (Cytochrome P450 3A7)

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