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Inje cocktail
- Development stage
- Phase 1
- Lead developer
- Inje University College of Medicine
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
The Inje cocktail is a validated combination of five probe drugs designed for high-throughput in vivo phenotyping of major human cytochrome P450 (CYP) enzyme activities. It is used primarily in clinical pharmacology research to simultaneously assess the metabolic activity of CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A enzymes. The five components are caffeine (CYP1A2), losartan (CYP2C9), omeprazole (CYP2C19), dextromethorphan (CYP2D6), and midazolam (CYP3A). Each drug serves as a specific substrate for its respective enzyme isoform. The mechanism involves administering all five drugs together and measuring their plasma or urine metabolite ratios to determine individual enzyme activity[1][3][8]. This approach enables efficient evaluation of potential drug-drug interactions or genetic differences in metabolism.
- Brand names
- Inje cocktail
- Other names
- Inje cocktailfive-drug CYP probe cocktail
02
Targets
CYP1A2 (Cytochrome P450 1A2)CYP2C19 (Cytochrome P450 2C19)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)CYP2D6 (Cytochrome P450 2D6)CYP3A7 (Cytochrome P450 3A7)
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