Drug intelligence / Profile preview

iNK010

Development stage
Preclinical
Lead developer
Shanghai Enkai Cell Technology
Modality
CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, iPSCs → Pluripotent Stem Cells → Stem Cell Therapies → Cell Therapies
Administration
Intravenous
01

Overview

iNK010 is a chimeric antigen receptor (CAR)-engineered natural killer (NK) cell therapy derived from induced pluripotent stem cells (iPSCs). Developed by Cell Inspire Biotechnology, it specifically targets G-protein coupled receptor family C group 5 member D (GPRC5D), a protein highly expressed on malignant plasma cells in multiple myeloma. To enhance therapeutic efficacy, the cells are engineered to secrete Interleukin-15 (IL-15), which promotes the persistence, proliferation, and antitumor activity of the NK cells within the tumor microenvironment. iNK010 is currently in preclinical development, with studies focused on in vivo PK/PD validation and investigator-initiated trials (IIT).

02

Targets

GPRC5DIL-15R (Interleukin 15 receptor alpha/interleukin 15 complex)

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