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iNK011
- Development stage
- Preclinical
- Lead developer
- Cell Inspire Biotechnology
- Modality
- iPSCs → Pluripotent Stem Cells → Stem Cell Therapies → Cell Therapies, CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
- Administration
- Intravenous
01
Overview
iNK011 is an investigational chimeric antigen receptor (CAR)-engineered induced pluripotent stem cell (iPSC)-derived natural killer (NK) cell therapy developed by Cell Inspire Biotechnology. It is designed to target Human Epidermal Growth Factor Receptor 2 (HER2) expressing solid tumors. The cells are further engineered to secrete Interleukin-15 (IL-15), a cytokine that promotes the survival, proliferation, and persistence of NK cells within the tumor microenvironment, thereby enhancing anti-tumor efficacy. iNK011 is currently in preclinical development, with studies focusing on in vivo PK/PD validation and investigator-initiated trials (IIT).
02
Targets
IL-15R (Interleukin 15 receptor alpha/interleukin 15 complex)ERBB2 (Erb-b2 receptor tyrosine kinase 2)
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