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INM-176

Development stage: Phase 3
Lead developer: WhanIn Pharm
Modality: Small Molecules
Administration: Oral

Overview

INM-176 is a standardized ethanolic extract derived from the root of Angelica gigas Nakai, a plant traditionally used in Korean medicine. The extract contains bioactive compounds including decursin and decursinol, which function primarily as acetylcholinesterase (AChE) inhibitors. This mechanism increases brain levels of acetylcholine, a neurotransmitter essential for memory and cognition. INM-176 also exhibits neuroprotective properties through anti-inflammatory activities and protection against beta-amyloid peptide-induced neuronal damage. It has been investigated primarily for cognitive disorders including Alzheimer's disease and age-related memory impairment.

Other names: Alzheimer's therapeutic, Whanin PharmaceuticalsAnti-beta amyloid/AChE inhibitorAnti-beta amyloid/acetylcholinesterase inhibitor

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)AcetylcholinesteraseTNFA (Tumor necrosis factor alpha (soluble))NOS2 (Nitric Oxide Synthase 2)IL1B (Interleukin-1 beta)

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