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INO-464 + nab-paclitaxel
- Development stage
- Unknown
- Lead developer
- NovaQuest Capital Management
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Oral, Intravenous
01
Overview
INO-464 (seviteronel) is an orally bioavailable dual inhibitor of cytochrome P450c17a (CYP17) 17,20-lyase and androgen receptor (AR), developed for the treatment of hormone-driven cancers such as metastatic castration-resistant prostate cancer. It competitively inhibits both wild-type and mutated forms of the AR and selectively targets CYP17 lyase over hydroxylase activity[10]. Nab-paclitaxel is a nanotechnology-based formulation of paclitaxel bound to albumin nanoparticles, designed to improve solubility and delivery. It acts as a microtubule inhibitor that disrupts cell division in cancer cells[2][9]. The combination "INO-464 + nab-paclitaxel" represents an investigational regimen combining hormonal pathway inhibition with cytotoxic chemotherapy for enhanced antitumor efficacy.
- Other names
- nanoparticle albumin-bound paclitaxelalbumin-bound paclitaxel
02
Targets
AR (Adrenergic receptors)CYP17A1 (Steroid 17-alpha-hydroxylase/C17,20 lyase)TUBA (Tubulin alpha/beta dimer)
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