Drug intelligence / Profile preview

inorganic nitrate + inorganic nitrite

Development stage
Unknown
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

Inorganic nitrate and nitrite are water-soluble compounds that serve as substrates for nitric oxide (NO) production through a pathway independent of the traditional NO synthase enzymes. This combination has demonstrated therapeutic potential in various cardiovascular and metabolic conditions, including heart failure, hypertension, and type 2 diabetes. Unlike organic nitrates, inorganic nitrate/nitrite therapy does not lead to tolerance with chronic use, making it potentially more suitable for long-term treatment. Common sources include green leafy vegetables, with beetroot juice being frequently used in clinical studies.

02

Targets

Hb (Hemoglobin)NO2- (Nitrite)

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