Drug intelligence / Profile preview

inotodiol

Development stage
Preclinical
Modality
Small Molecules
Administration
Intravenous, Intraperitoneal, Oral
01

Overview

Inotodiol is a lanostane-type triterpenoid compound derived from the Chaga mushroom (*Inonotus obliquus*). It exhibits strong biological activities, including anti-inflammatory, antioxidant, anti-tumor, anti-aging, and anti-allergic properties. Inotodiol promotes the atypical maturation of dendritic cells, enhancing T cell proliferation without inducing pro-inflammatory cytokine production. It also inhibits the proliferation of cancer cells and induces apoptosis in human cervical cancer HeLa cells by regulating cell cycle proteins and apoptosis-related genes.

Other names
Triterpenoid compoundOxysterol(22R)-Lanosta-8,24-diene-3β,22-diol
02

Targets

CD86 (T-lymphocyte activation antigen CD86)MHC I (MHC class I})TP53 (Cellular Tumor Antigen p53 R175H)CD40 (Cluster of differentiation 40 receptor)MHC II (Major histocompatibility complex class II receptor)

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