Drug intelligence / Profile preview

INP105

Development stage
Phase 1
Lead developer
Impel Pharmaceuticals
Modality
Small Molecules
Administration
Intranasal
01

Overview

INP105 is a proprietary upper nasal formulation of olanzapine delivered using Impel Pharmaceuticals' Precision Olfactory Delivery (POD) technology. It is being developed for the rapid treatment of acute agitation and aggression associated with conditions such as autism spectrum disorder, bipolar I disorder, and schizophrenia. The device enables non-invasive administration by patients or caregivers, achieving peak plasma levels of olanzapine significantly faster than intramuscular injection or orally disintegrating tablets. This approach aims to provide a safe, effective alternative to injectable treatments for acute agitation outside hospital settings[1][2][3][4][5][6][7][8].

Other names
intranasal olanzapinePOD-olanzapine
02

Targets

HTR2A (Serotonin receptor 5-HT2A)HTR2C (5-hydroxytryptamine 2C receptor)HRH1 (Histamine H1 Receptor)ADRA1A (α1A)DRD2 (Dopamine D2 Receptor)

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