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INP20

Development stage: Phase 2
Lead developer: InnoUp Farma
Modality: Nanoparticles → Drug Delivery Systems, Vaccines & Immunotherapeutics
Administration: Oral

Overview

INP20 is an oral vaccine immunotherapy being developed by InnoUp Farma for the treatment of peanut allergy. It consists of nanoparticles encapsulating peanut extract, designed to induce immune tolerance and reduce allergic reactions to peanuts. The formulation leverages nanotechnology to enhance mucosal delivery and antigen presentation, aiming for improved safety and efficacy compared to traditional immunotherapies. Mechanistically, INP20 acts as an immunostimulant, with evidence suggesting it functions as a Toll-like receptor 2 (TLR2) and Toll-like receptor 4 (TLR4) agonist, modulating the immune response toward tolerance rather than hypersensitivity. The drug is currently in phase I/II clinical trials for peanut hypersensitivity[1][4][5][6].

Other names: Peanut allergy immunotherapy - InnoUp Farma

Targets

TLR2 (Toll-like Receptor 2)TLR4 (Toll-like receptor 4)

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