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instant MSC product + autologous chondrocytes
- Development stage
- Unknown
- Lead developer
- University Medical Center Utrecht
- Modality
- Cell Therapies
- Administration
- Intraarticular
01
Overview
IMPACT (Instant MSC Product accompanying Autologous Chondron Transplantation) is a combined cell therapy developed by the University Medical Center Utrecht for the treatment of focal articular cartilage defects in the knee. The product consists of a combination of allogeneic, bone marrow-derived mesenchymal stromal cells (MSCs) and autologous chondrons (chondrocytes with their native pericellular matrix) isolated from the patient's own debrided cartilage. Administered in a single-stage surgical procedure, the allogeneic MSCs act as trophic signaling units that stimulate the autologous chondrons to regenerate hyaline-like cartilage tissue, rather than the MSCs themselves differentiating into cartilage. This approach aims to provide a rapid, one-step alternative to traditional two-stage autologous chondrocyte implantation (ACI) procedures.
- Other names
- IMPACTInstant MSC Product accompanying Autologous Chondron Transplantationallogeneic mesenchymal stromal cells + autologous chondrons
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