Drug intelligence / Profile preview

insulin + Nisha-Amalaki

Development stage
Unknown
Modality
Recombinant Proteins and Enzymes, Small Molecules
Administration
Subcutaneous, Oral, Intravenous
01

Overview

This is a combination therapy consisting of two components: - **Insulin**: A peptide hormone produced by the pancreas that regulates blood glucose levels by facilitating cellular uptake of glucose. It is a mainstay pharmaceutical treatment for both type 1 and advanced type 2 diabetes mellitus. - **Nisha-Amalaki** (also known as Nishamalaki): An Ayurvedic herbal formulation composed primarily of equal parts turmeric (*Curcuma longa*, also called Haridra or Nisha) and Indian gooseberry (*Emblica officinalis*, also called Amalaki). This combination has demonstrated antihyperglycemic, antioxidant, anti-inflammatory, and potential beta-cell protective effects in preclinical studies. Clinical trials suggest it can improve glycemic control, reduce HbA1c levels, enhance insulin sensitivity (lower HOMA-IR), lower fasting/postprandial blood sugar levels, improve lipid profiles (reduce triglycerides/total cholesterol), and may serve as an adjuvant to standard antidiabetic therapies[2][4][5][6][7]. The mechanism involves both direct hypoglycemic action—possibly via stimulation of pancreatic beta cells—and indirect metabolic modulation through antioxidant activity[6]. The combination "insulin + Nisha-Amalaki" would be used in the management of diabetes mellitus—particularly type 2 diabetes—as an integrative approach combining conventional pharmacotherapy with traditional herbal medicine. There are no widely recognized brand names for this specific combination; it represents a therapeutic regimen rather than a single commercial product.

Other names
insulin and Nisha-Amalakiinsulin plus Nisha-Amalakiinsulin + Nishamalakiinsulin and Nishamalaki
02

Targets

INSR (Insulin receptor)

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