insulin detemir + insulin isophane

Insulin detemir + Insulin Insulatard refers to a combination or comparative regimen of two basal insulin products: insulin detemir (a long-acting analogue) and Insulin Insulatard (an intermediate-acting NPH human insulin). Insulin detemir, marketed as Levemir, utilizes a fatty acid chain to bind to albumin, resulting in slow absorption and a prolonged duration of action. Insulin Insulatard is a suspension of human insulin with protamine and zinc. This specific combination was evaluated in a Phase 4 randomized crossover trial (NCT00742976) to determine if switching from NPH insulin to insulin detemir affects renal sodium handling, extracellular volume, and body weight in patients with type 2 diabetes mellitus. The study found that insulin detemir was associated with significant weight loss compared to NPH insulin, potentially due to reduced renal sodium retention.

Brand names

LevemirInsulatard

Other names

insulin detemir + NPH insulininsulin detemir + neutral protamine Hagedorn insulin